Lofene is a brand name commonly associated with Diclofenac Sodium, a nonsteroidal anti-inflammatory drug (NSAID) used to reduce inflammation, pain, and swelling. It works by inhibiting cyclooxygenase (COX) enzymes, which are involved in the production of prostaglandins—chemicals responsible for inflammation and pain. Lofene is frequently prescribed for arthritis, musculoskeletal disorders, and other inflammatory conditions.